Berberine vs. Metformin – Which One Should You Choose?

Let’s compare Berberine vs Metformin!

As we age, we are increasingly faced with the reality of mortality. Our limbs aren’t as flexible anymore, we don’t move like we used to and the body is generally slower at performing tasks like rebuilding muscle and bone.

Moreover, autophagy sets in, reducing the cellular content turnover and the body ultimately finds it difficult to suppress oxidation. The good news is there is something we can do to improve the body’s repair mechanism so that we may extend our lifespan.

We all know that people who eat a healthy balanced diet and exercise regularly over long periods of time tend to look and feel decades younger.

That’s because living a healthy lifestyle can help extend longevity by enhancing the repair functions of the body. Recent anti-aging research shows that taking geroprotector supplements known as Metformin and Berberine can significantly boost the body’s repair function as well.

If you don’t have time to read this article and just want to find the best insulin mimetic, click the button below!

It contains berberine and many other useful ingredients to help with lowering blood sugar. It’s by far one of the best products on the market right now.

What is Berberine?

The bioactive compound known as Berberine is specifically extracted from a group of plants known as Berberis shrubs, hence the name.

It’s part of the alkaloid group of compounds. Due to its characteristic yellow color, Berberine is often used as a dye.

Berberine vs metformin

Although mainstream medicine has only recently become aware of Berberine, the Chinese have been using it as a versatile form of treatment for centuries.

Thanks to scientific studies, we now know of the huge health benefits of this health-enhancing compound, especially when it comes to prolonging our lifespan.

How Does Berberine Work?

To date, hundreds of studies have been conducted on Berberine. All of these studies unequivocally show that Berberine specifically affects our biological systems. What makes Berberine so unique is the fact that it goes straight to your bloodstream as soon as you consume it. From there, it travels to your cells where it connects itself to “molecular targets” that need changing or updating.

Once inside your cells, Berberine gets to work by activating the AMP-activated protein kinase (AMPK) enzyme. This enzyme is also responsible for regulating your metabolism, and you can find it almost everywhere in your body, including your heart, liver, kidneys muscles and even in your brain.

Berberine doesn’t stop there. Because it also has an effect on your genes by stimulating the molecules within your body’s cells.

What is Metformin?

The prescription drug known as Metformin is often recommended for patients who suffer from health conditions. These are conditions like type 2 diabetes and high blood sugar.

It’s available as an oral solution and as an oral tablet as well.

There are two types of Metformin tablets available on the market, namely extended-release tablets and immediate-release tablets.

The extended-release tablets are available in the form of well-known drugs like Glumeta, Fortamet and Glucophage XR. The immediate release aspect of the drug is mainly available as the drug Glucophage.

There are also generic versions of both tablet types and these are usually more affordable. However, you’re less likely to get the strength variety that’s available with big-brand drugs.

It’s often recommended to use Metformin tablets in conjunction with a balanced healthy diet and regular exercise in order to reap its true benefits.

It’s also common for doctors to recommend that patents take it in combination with other drugs as part of a complete therapy.

How Does Metformin Work?

The Metformin drug is part of the biguanides group of drugs that work similarly to one another in treating certain conditions.

This is how Metformin works:

  • It reduces the amount of glucose that goes into your bloodstream
  • It enables your liver to excrete less glucose
  • It improves your body’s ability to use insulin

Insulin is a type of hormone whose job it is to regulate blood sugar levels so that there’s isn’t too much sugar in the blood.

Berberine vs Metformin Bodybuilding

What’s this video about the difference between Berberine vs Metformin for Bodybuilding purposes.

Both of these compounds are very popular amongst bodybuilders.

If I personally had to compare berberine vs metformin for bodybuilding purposes, I’d go with Berberine.

It’s easy to get and there is plenty of research to back it up.

Comparing Berberine vs Metformin

When you look at it from a cellular level, both Metformin and Berberine work in a similar way. Both compounds create an environment that encourages healthy blood sugar levels. Both compounds work to enhance the action of the AMPK enzyme, which is usually triggered during fasted states or when you’re engaged in intense exercise.

berberine vs metformin

When AMPK is activated, there’s a higher uptake of fatty acids and glucose from the blood, the storage of fat and glucose is halted, and your cells have access to more energy. 

AMPK facilitates quick and long-lasting results by immediately phosphorylating enzymes as well as their transcription factors. Metformin facilitates faster cellular energy uptake just as well as Berberine, and this, in turn, facilitates the processing of energy storage.

When AMPK is triggered, it stimulates the transportation chain of electrons which promotes glucose consumption. Both compounds have the ability to specifically hinder complex 1 which belongs to the electron transport chain. This reduces the efficiency of the AP production process which your body interprets as being on a fasted state or a restricted calorie diet.

It’s important to note here that there currently isn’t enough evidence to show how the action mechanism of these compounds works but available research does show that Berberine reduces LDL cholesterol which is the harmful kind of cholesterol. On the other hand, Metformin reduces the amount of triglycerides, LDL cholesterol and fatty acid levels in your body.

Is it okay to take both Metformin and Berberine at the same time?

Evidence shows that these two compounds are actually complementary.

According to research done on mice, Berberine can actually promote healthy lactic acid levels when used in conjunction with Metformin.

In a nutshell, when comparing Berberine vs Metformin they have more things in common than they have differences.

Sure they may affect your body in different ways but they pretty much work on the same metabolic pathways, which is why it’s often recommended to use them in combination if your intention is to achieve physical longevity.

Using Berberine and Metformin

Metformin and Berberine are undoubtedly the most prominent geroprotectors on the market. Although they’re famous for promoting longevity and optimal health, there’s no conclusive evidence to fully support these claims.

Metformin is a prescription drug that you can only get through the recommendation of your doctor.

Berberine, on the other hand, is an over-the-counter drug that’s relatively easy and affordable to access. However, it’s still a good idea to consult with your physician before you purchase it.

When looking for a Berberine supplement to purchase, be sure to check its absorption rate and make sure that you’re buying it from a company that gets it from reputable manufacturers and suppliers.

Where to buy Berberine?

I currently use a supplement that contains Berberine but also other really good ingredients to lower blood sugar.

This product is by far one of the best insulin mimetic’s you can get. It works as a nutrtient partitioner and carbohydrate catalyst.

The product I am talking about is SLIN by Enhanced Athlete.

Insulin Mimetic

Which One Should You Choose

As you can see, both Metformin vs Berberine offers fantastic health benefits, from reducing cholesterol levels to regulating blood pressure and helping your cells work better.

Both of these compounds are great at helping your body thrive, and with so many similarities it’s hard to pick a winner.

However, if we had to choose between berberine vs metformin, then we’d definitely recommend Berberine.

This is one of the few available compounds that are able to activate AMPK. This sets into motion a chain of events that allows your body to regenerate from a molecular level.

Some of the key benefits offered by Berberine include “upgrading’ certain molecular targets throughout the different major organs in your body, regulating the metabolism, encouraging healthy blood sugar levels and helping to get rid of unhealthy cholesterol.

If you have personally compared berberine vs metformin, let me know down in the comments.

Berberine vs Metformin
  • Berberine
  • Metformin


  1. Joebodybuild March 22, 2019
  2. debra stegall January 26, 2020

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