TB-500 Review: How it works, dosages and side effects.

TB-500 is the synthetic version of a powerful protein known as Thymosin Beta-4. As such, TB-500 has potent healing properties that facilitate a speedy recovery from injuries. That’s why it’s commonly used in the animal racing world to improve performance and reduce the occurrence of injuries.

How TB-500 Works

TB- 500 basically regulates the process through which actin builds cells in the body. Actin is a protein that plays a huge role in the formation of muscle cells and it works together with myosin to build metabolism and improve motion.


TB-500’s healing properties make sense when you consider the fact that actin is involved in the formation and action of most of your body’s cells. The powerful combination of these peptides has the ability to promote positive cell growth, speed up the healing process and encourage cell migration and proliferation. This translates to the build-up of good inflammation that actually aids in faster healing.

TB-500 is a very agile protein that can travel through the bloodstream faster than most of the other proteins. That’s because it has a low molecular weight and a unique molecular structure that makes it very versatile. This is part of what makes it so effective at targeting specific injuries, whether acute or chronic. Of course, it comes with added benefits too like reduced inflammation, better flexibility and even improved hair growth!

There’s also talk that TB-500 can help heal a common injury known as “athlete’s heart”, which as the name implies, affects a lot of athletes. The type of high-level activity that athletes go through can put a lot of strain on the heart so if these rumors are proven true it would be good news for the industry. However, research is still underway to fully establish the effects of TB-500 on ventricular hypertrophy which is another word for damaged heart tissue.

While TB-500 is not necessarily recognized as a prescription veterinary drug, the racehorse industry has found numerous uses for it. Most trainers give it to their horses in order to prevent injuries or muscular adhesions ahead of competitions. MedivetEquine reports that TB-500 has the ability to positively affect mammals of all sizes in positive ways.

Some of the benefits it offers include:

  • Helps to regenerate blood cells
  • Reduces joint inflammation
  • Helps to heal wounds faster than usual while reducing pain and tissue scarring
  • Has been shown to heal diabetes in dogs
  • Works at the cellular level to regenerate organs and heal wounds
  • Improves endurance by affecting stamina levels

In humans, TB-500 is taken in the form of an injection and has been used to speedily heal wounds and injuries that would otherwise take months to recover from. Some have even taken it as an intervention for chronic injuries that don’t want to go away.

How To Use TB-500

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You can use intravenous, intramuscular or subcutaneous injections to deliver TB-500 into your bloodstream. Just make sure you wipe the rubber stopper and the area that you’re about to inject with an alcohol swab beforehand to minimize contamination and bacterial infection.

  • Intravenous Injection: This method is not for the faint of heart because it involves inserting the needle into the vein. This can be quite painful as the targeted veins are in areas that have sensitive skin like the back of the hand, the elbow or the wrist. For the best results, only try this method if you have nerves of steel or medical supervision.
  • Intramuscular Injection: This is another painful method because it involves actually stabbing the skin with an injection on the area of the injury.
  • Subcutaneous Injection: This is the simplest and least painful option of the three. All you have to do is pinch a small part of the skin anywhere on the body and insert the needle. For the best results, try to target an area that’s as close to the injury as possible.

A great way to get the substance into your system more effectively is to massage the area after you’ve injected it. This will help speed up absorption and make the peptide more effective.  

Recommended TB500 Dose

The recommended dosage of TB-500 is anything between 4 to 10 milligrams taken twice weekly. This is the initial dose which should be taken for the first 4 to 6 weeks in order to get your system used to it. After that, you can take half of that amount once per week for maintenance purposes. Later on, in your maintenance protocol, you’ll only have to take it once per month. This latter stage of the protocol can be taken during the training season and even while you prepare for competitions. It will aid in faster recovery and help you stay injury free as you push your body past its limits.

It’s important to note here that the dosage protocol that we’ve described above is the most commonly used but not necessarily the benchmark dosage recommendation. There’s currently no yardstick dosage protocol and the available information is based on observations of what has worked thus far for mammals undergoing athletic training. Experts recommend basing TB-500 dosage protocol and overall length of therapy on the unique needs of the particular animal.  D

Does TB-500 Have Side Effects?

Current research on TB-500 shows contradictory results. There are studies which reveal that it can exacerbate cancer cell growth, while other studies say that it actually prevents cancer. 

Physicians have observed higher Thymosin levels in cancer patients than in healthy individuals, which is what sparked rumors about TB-500’s role in increasing the cancer cells growth. But, further research showed that the presence of Thymosin Beta-4 boosted the production of white blood cells. This is why it tends to show up in areas with cancer cells, and instead of adding fuel to the fire it actually improves the body’s immune response.

Beyond this point, there isn’t a whole lot of data on TB-500 because very few studies have been conducted on it. The most common side-effect that has been observed by athletes and bodybuilders who use this peptide is that of extreme tiredness. Others report experiencing a head rush immediately after injecting it, but the feeling only lasts for a few minutes before things return to normal.

The Difference between TB-500 and BPC-157

Both of these peptides are known for their ability to facilitate quick recovery from wounds and injuries. The difference between the two lies in their origin. BPC-157 is a bit more organic because it’s derived from a natural Body Protecting Peptide from the gastrointestinal system. This peptide works to naturally heal ulcers and improve digestion. Therefore, taking BPC-157 aids in the recovery of the connective tissues that are affected when an injury occurs, and it promotes gastrointestinal health. Its effect is comparable to that of Thymosin Beta-4 in this regard. It’s interesting to note that BPC-157 and TB-500 offer similar recovery benefits as well.

With that said, TB-500 has received far better reviews for its overall benefits on muscle tissue when compared to BPC-157. Users say that TB-500 is really great at helping to grow healthy muscle tissue, and it’s more effective when it comes to facilitating faster recovery. In fact, it has even been suggested that TB-500 is on the same level as Thymosin Beta-4.

Nevertheless, these two peptides work really well together which is why some athletes prefer to stack them in order to maximize results. This is also why the ROHEALIX peptide was created. It’s a combination of BPC-157 and TB-500 and it makes it that much easier for you to get the best of both worlds.

Where to Buy TB-500

TB-500 is sold as Thymosin Beta-4 and it’s widely available on peptide supplier websites, where it’s sold only for research purposes. How you use it, however, is entirely up to you.

The type of TB-500 that’s sold online comes in powder form, and it must be added to bacteriostatic water before consumption. That’s how you get the most out of the peptide, and you have to mix it thoroughly so that you get more of it into your bloodstream.

Once you have the mixture, you can then transfer it to an insulin syringe. This allows you to take the TB-500 in a number of ways, including intravenously, subcutaneously and intramuscularly.


Peptides are like the black sheep of the supplement world and for a good reason. Not much research has been conducted on them and most of the information available is either based on animal studies or anecdotal evidence.

This means that taking peptides like BPC-157 or TB-500 is a calculated risk that you have to take with your eyes wide open. Luckily, there are some great resources out there that you can consult for more information. However, the responsibility is on you to keep up with the latest research developments.

Evidence suggests that TB-500 can be beneficial for speeding up recovery from injuries and wounds while promoting muscle growth. So it might be worth your while to try it out. Just make sure to take it under medical supervision at first if you can and stick to the recommended dosage.

TB-500 Review
  • Healing properties
  • Recovery
  • Side effects


  1. Vigor January 11, 2019
    • BL August 18, 2019
  2. Kevin May 15, 2019
  3. Pedro September 11, 2019

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